What is trifluoroacetic anhydride?

Trifluoroacetic anhydride, also known as TFAA, is a chemical compound with the formula (CF3CO)2O. It is a colorless liquid with a strong odor similar to acetic anhydride.

Trifluoroacetic anhydride is commonly used as a reagent in organic synthesis, particularly in the acylation of alcohols, amines, and thiols. It is also used as a derivatizing agent for analysis by mass spectrometry and as a protecting group for amines in peptide synthesis.

This compound is highly reactive and should be handled with caution. It is corrosive to metals and can cause severe burns on skin contact. Trifluoroacetic anhydride should be stored in a cool, dry place away from heat, sparks, and open flames.

Overall, trifluoroacetic anhydride is a versatile reagent in organic chemistry with various applications in synthesis and analysis.